The inner surface of the intestines is lined with a single layer of intestinal cells. Fluids and nutrients in the intestine are absorbed through the finger-like projections of these cells. Tight junctions between these cells prevent toxins, bacteria and undigested food particles in the intestine from passing into the bloodstream. If these tight junctions and/or cells are damaged in some way, everything in the intestine, wanted or unwanted, suitable or unsuitable, crosses the intestinal barrier and enters the bloodstream. This is called increased intestinal permeability (leaky gut).
This condition contributes to the development of diseases such as:
- Celiac disease
- Type 1 diabetes
- Irritable bowel syndrome
- Food intolerances
- Autoimmune diseases
- Depression
- Hashimoto's thyroiditis
- Metabolic syndrome
and others.
A stool test is performed to diagnose leaky gut syndrome. The test looks at a protein known as “zonulin”. Zonulin reflects the integrity of the intestinal barrier. It is a protein that holds together or repairs the tight junctions. An elevated zonulin level indicates increased intestinal permeability.
To correct increased intestinal permeability:
- Take prebiotic and probiotic supplements
- Eat high-fiber foods and increase your vegetable intake
- Do not eat foods containing gluten
- Avoid refined foods and foods with additives
- Do not eat refined foods
- Do not use sugar
- Do not eat processed, packaged products
- Do not eat processed meat products
- Do not consume excessive amounts of saturated fat
- Do not drink alcohol or smoke
- Limit your caffeine intake
The information on our website is not intended to direct individuals to any treatment. Do not take any diagnostic or treatment steps without consulting your doctor. The content does not contain information about İzmir Can Hastanesi's therapeutic healthcare services.


